Antitumor effect of mifepristone on human endometrial stromal cell line

نویسندگان

چکیده

Background/Aim. The main cause for development of endometrial hyperplasia is unopposed effect estrogen on cells. aim our study was to investigate and compare cytotoxic apoptotic effects mifepristone human stromal cell line the first time. Both percentage cells were determined after 24 h treatment with different doses mifepristone. Methods. evaluated by viability assay while using flow cytometry. Determination confirmed immunofluorescence method determining expression localization active Bax Bcl-2 proteins. Results. Our results indicated that induced (ThESC) through changes in level Conclusion. Cytotoxic pro-apoptotic vitro investigated this It crucial point out expressed both ThESC line. may contribute determination proteins involved apoptosis lowest

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ژورنال

عنوان ژورنال: Vojnosanitetski Pregled

سال: 2021

ISSN: ['2406-0720', '0042-8450']

DOI: https://doi.org/10.2298/vsp190226104l